Effect of aging on magnetic resonance measures differentiating progressive supranuclear palsy from Parkinson's disease.
Identifieur interne : 000593 ( Main/Exploration ); précédent : 000592; suivant : 000594Effect of aging on magnetic resonance measures differentiating progressive supranuclear palsy from Parkinson's disease.
Auteurs : Maurizio Morelli [Italie] ; Gennarina Arabia ; Demetrio Messina ; Basilio Vescio ; Maria Salsone ; Carmelina Chiriaco ; Paolo Perrotta ; Federico Rocca ; Giuseppe Lucio Cascini ; Gaetano Barbagallo ; Salvatore Nigro ; Aldo QuattroneSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
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- MESH :
Abstract
Imaging measurements, such as the ratio of the midsagittal areas of the midbrain and pons (midbrain/pons) and the Magnetic Resonance Parkinsonism Index (MRPI), have been proposed to differentiate progressive supranuclear palsy (PSP) from Parkinson's disease (PD). However, abnormal midbrain/pons values suggestive of PSP have also been reported in elderly individuals and in patients with PD. We investigated the effect of aging on single or combined imaging measurements of the brainstem. We calculated the midbrain/pons and the MRPI (the ratio of the midsagittal areas of the pons and the midbrain multiplied by the ratio of the middle cerebellar peduncle and superior cerebellar peduncle widths) in 152 patients affected by PD, 25 patients with PSP, and a group of 81 age-matched and sex-matched healthy controls using a 3-Tesla magnetic resonance imaging scanner. In healthy controls, aging was negatively correlated with midsagittal area of the midbrain and midbrain/pons values. In patients with PD, in addition to the effect of aging, the disease status further influenced the midbrain/pons values (R(2) = 0.23; P < 0.001). In both groups, MRPI values were not influenced either by aging or by disease status. No effect of aging on either midbrain/pons or MRPI values was shown in the patients with PSP. Our findings indicated that the MRPI was not significantly influenced by aging or disease-related changes occurring in PD; whereas, in contrast, the midbrain/pons was influenced. Therefore, the MRPI appears to be a more reliable imaging measurement compared with midbrain/pons values for differentiating PSP from PD and controls in an elderly population.
DOI: 10.1002/mds.25821
PubMed: 24573655
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Messina</name></author><author><name sortKey="Vescio, Basilio" sort="Vescio, Basilio" uniqKey="Vescio B" first="Basilio" last="Vescio">Basilio Vescio</name></author><author><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name></author><author><name sortKey="Chiriaco, Carmelina" sort="Chiriaco, Carmelina" uniqKey="Chiriaco C" first="Carmelina" last="Chiriaco">Carmelina Chiriaco</name></author><author><name sortKey="Perrotta, Paolo" sort="Perrotta, Paolo" uniqKey="Perrotta P" first="Paolo" last="Perrotta">Paolo Perrotta</name></author><author><name sortKey="Rocca, Federico" sort="Rocca, Federico" uniqKey="Rocca F" first="Federico" last="Rocca">Federico Rocca</name></author><author><name sortKey="Cascini, Giuseppe Lucio" sort="Cascini, Giuseppe Lucio" uniqKey="Cascini G" first="Giuseppe Lucio" last="Cascini">Giuseppe Lucio Cascini</name></author><author><name sortKey="Barbagallo, Gaetano" sort="Barbagallo, Gaetano" uniqKey="Barbagallo G" first="Gaetano" last="Barbagallo">Gaetano Barbagallo</name></author><author><name sortKey="Nigro, Salvatore" sort="Nigro, Salvatore" uniqKey="Nigro S" first="Salvatore" last="Nigro">Salvatore Nigro</name></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24573655</idno><idno type="pmid">24573655</idno><idno type="doi">10.1002/mds.25821</idno><idno type="wicri:Area/PubMed/Corpus">000574</idno><idno type="wicri:Area/PubMed/Curation">000574</idno><idno type="wicri:Area/PubMed/Checkpoint">000609</idno><idno type="wicri:Area/Ncbi/Merge">003F23</idno><idno type="wicri:Area/Ncbi/Curation">003F23</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F23</idno><idno type="wicri:Area/Main/Merge">000593</idno><idno type="wicri:Area/Main/Curation">000593</idno><idno type="wicri:Area/Main/Exploration">000593</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of aging on magnetic resonance measures differentiating progressive supranuclear palsy from Parkinson's disease.</title><author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neurology, University "Magna Graecia", Germaneto, Catanzaro, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University "Magna Graecia", Germaneto, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name></author><author><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name></author><author><name sortKey="Vescio, Basilio" sort="Vescio, Basilio" uniqKey="Vescio B" first="Basilio" last="Vescio">Basilio Vescio</name></author><author><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name></author><author><name sortKey="Chiriaco, Carmelina" sort="Chiriaco, Carmelina" uniqKey="Chiriaco C" first="Carmelina" last="Chiriaco">Carmelina Chiriaco</name></author><author><name sortKey="Perrotta, Paolo" sort="Perrotta, Paolo" uniqKey="Perrotta P" first="Paolo" last="Perrotta">Paolo Perrotta</name></author><author><name sortKey="Rocca, Federico" sort="Rocca, Federico" uniqKey="Rocca F" first="Federico" last="Rocca">Federico Rocca</name></author><author><name sortKey="Cascini, Giuseppe Lucio" sort="Cascini, Giuseppe Lucio" uniqKey="Cascini G" first="Giuseppe Lucio" last="Cascini">Giuseppe Lucio Cascini</name></author><author><name sortKey="Barbagallo, Gaetano" sort="Barbagallo, Gaetano" uniqKey="Barbagallo G" first="Gaetano" last="Barbagallo">Gaetano Barbagallo</name></author><author><name sortKey="Nigro, Salvatore" sort="Nigro, Salvatore" uniqKey="Nigro S" first="Salvatore" last="Nigro">Salvatore Nigro</name></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aging (pathology)</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mesencephalon (pathology)</term><term>Middle Aged</term><term>Parkinson Disease (pathology)</term><term>Pons (pathology)</term><term>Supranuclear Palsy, Progressive (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term><term>Mesencephalon</term><term>Parkinson Disease</term><term>Pons</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Imaging measurements, such as the ratio of the midsagittal areas of the midbrain and pons (midbrain/pons) and the Magnetic Resonance Parkinsonism Index (MRPI), have been proposed to differentiate progressive supranuclear palsy (PSP) from Parkinson's disease (PD). However, abnormal midbrain/pons values suggestive of PSP have also been reported in elderly individuals and in patients with PD. We investigated the effect of aging on single or combined imaging measurements of the brainstem. We calculated the midbrain/pons and the MRPI (the ratio of the midsagittal areas of the pons and the midbrain multiplied by the ratio of the middle cerebellar peduncle and superior cerebellar peduncle widths) in 152 patients affected by PD, 25 patients with PSP, and a group of 81 age-matched and sex-matched healthy controls using a 3-Tesla magnetic resonance imaging scanner. In healthy controls, aging was negatively correlated with midsagittal area of the midbrain and midbrain/pons values. In patients with PD, in addition to the effect of aging, the disease status further influenced the midbrain/pons values (R(2) = 0.23; P < 0.001). In both groups, MRPI values were not influenced either by aging or by disease status. No effect of aging on either midbrain/pons or MRPI values was shown in the patients with PSP. Our findings indicated that the MRPI was not significantly influenced by aging or disease-related changes occurring in PD; whereas, in contrast, the midbrain/pons was influenced. Therefore, the MRPI appears to be a more reliable imaging measurement compared with midbrain/pons values for differentiating PSP from PD and controls in an elderly population.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><name sortKey="Barbagallo, Gaetano" sort="Barbagallo, Gaetano" uniqKey="Barbagallo G" first="Gaetano" last="Barbagallo">Gaetano Barbagallo</name><name sortKey="Cascini, Giuseppe Lucio" sort="Cascini, Giuseppe Lucio" uniqKey="Cascini G" first="Giuseppe Lucio" last="Cascini">Giuseppe Lucio Cascini</name><name sortKey="Chiriaco, Carmelina" sort="Chiriaco, Carmelina" uniqKey="Chiriaco C" first="Carmelina" last="Chiriaco">Carmelina Chiriaco</name><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name><name sortKey="Nigro, Salvatore" sort="Nigro, Salvatore" uniqKey="Nigro S" first="Salvatore" last="Nigro">Salvatore Nigro</name><name sortKey="Perrotta, Paolo" sort="Perrotta, Paolo" uniqKey="Perrotta P" first="Paolo" last="Perrotta">Paolo Perrotta</name><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><name sortKey="Rocca, Federico" sort="Rocca, Federico" uniqKey="Rocca F" first="Federico" last="Rocca">Federico Rocca</name><name sortKey="Salsone, Maria" sort="Salsone, Maria" uniqKey="Salsone M" first="Maria" last="Salsone">Maria Salsone</name><name sortKey="Vescio, Basilio" sort="Vescio, Basilio" uniqKey="Vescio B" first="Basilio" last="Vescio">Basilio Vescio</name></noCountry><country name="Italie"><noRegion><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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